At Mom Genes, we’re dedicated to understanding the genetic factors that contribute to postpartum depression (PPD). Thanks to the DNA contributions from many moms like you, we’re making significant strides in our research. Here’s what we’ve found so far:
What We Did:
We conducted a Genome-Wide Association Study (GWAS) across genetic data from thousands of mothers who have experienced PPD. A GWAS is used to look for small variations in DNA across a large group of people by comparing the DNA of people with a specific condition such as PPD, to those without it. By doing this, we can identify specific genetic differences that are more common in people with the condition.
Key Findings:
We discovered specific genetic markers that are more common in moms with PPD. These markers act as tiny flags in your DNA, helping us understand why some mothers experience PPD while others do not. While these markers are a promising start, we need more data to develop a comprehensive understanding of PPD’s genetic roots.
The GWAS suggests that PPD shares a very high genetic similarity with major depressive disorder. PPD also had significant genetic correlations to other mood disorders like bipolar II disorder as well as other mental health conditions, such as difficulties with sleep, and aspects of reproductive health.
We also studied specific tissues and cell types to see if there was a higher occurrence of PPD-related genetic variations. The genetic variations we found are likely to affect specific types of neurons in the brain. Notably, GABAergic neurons are most likely affected, which is significant because the only FDA-approved medication for treating PPD enhances the function of these neurons. By altering GABA activity, allopregnanolone helps to reduce anxiety and stress, and can improve mood.
Why It Matters
By knowing more about the genetic factors, we can start to piece together the complex puzzle of what causes PPD. Understanding the genetic roots of PPD can lead to new, more effective treatments tailored to individual genetic profiles.
Your DNA contributions are invaluable. They help us conduct this groundbreaking research that wouldn’t be possible otherwise. Every sample we analyze brings us one step closer to making PPD a condition we can predict, understand, and treat effectively.
Thank you for being part of this important journey. Together, we can make a real difference in the lives of mothers everywhere.